Regulation of cellular response to transforming growth factor beta stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP5L, RBFA, and NDRG4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to transforming growth factor beta stimulus activity versus LRP5L in OV (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRP5L →	+0.658	+0.181	.004	.005	3	3
OV	RBFA →	+0.590	+0.298	<.001	<.001	3	3
UCEC	NDRG4 →	+1.093	+0.266	.006	.003	3	3
UCEC	PRDM5 →	+1.458	+0.253	.005	.003	3	3
UCEC	RNF150 →	+2.016	+0.240	<.001	.003	3	3
UCEC	DNMT3AP1 →	+1.080	+0.284	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903844 vs LRP5L — OV

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