Regulation of cellular response to transforming growth factor beta stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, TMPO, and CHAF1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to transforming growth factor beta stimulus activity versus NASP in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NASP →	+0.552	+0.319	<.001	.009	3	6
BLOOD_Leukemia	TMPO →	+0.870	+0.221	.001	<.001	3	5
BONE	CHAF1A →	+1.036	+0.291	.007	.005	2	6
LUNG_SCLC	IFT81 →	+0.793	+0.245	.006	.001	3	4
BLOOD_Myeloma	SDHAF4 →	+1.597	+0.157	.007	.002	3	4
LUNG_SCLC	DCAF16 →	+0.823	+0.248	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903844 vs NASP — BLOOD_Leukemia

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