Negative regulation of miRNA processing

Across TCGA patient cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLG, ITIH3, and S100A12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of miRNA processing activity versus PLG in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLG →	+0.593	+0.037	.003	.001	3	6
OV	ITIH3 →	+0.809	+0.048	<.001	<.001	3	5
COAD	S100A12 →	+1.214	+0.032	.001	.002	3	4
COAD	AZU1 →	+0.918	+0.030	<.001	.004	3	4
COAD	CAMP →	+1.249	+0.031	<.001	.003	3	4
LUAD	CP →	+0.318	+0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903799 vs PLG — COAD

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