Negative regulation of miRNA processing

Across TCGA patient cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAMP, TP53, and RN7SL105P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of miRNA processing activity versus HAMP in LSCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HAMP →	+0.317	+0.427	<.001	<.001	3	3
OV	TP53 →	+0.956	+0.377	<.001	<.001	3	3
PDAC	RN7SL105P →	+0.442	+0.607	.004	.002	3	3
GBM	CYTH1 →	+0.336	+0.159	.003	.002	3	3
CCRCC	UQCC2 →	-0.252	-0.593	.005	.007	3	2
GBM	LRMDA →	+0.653	+0.178	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903799 vs HAMP — LSCC

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