Negative regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT3, IL6, and OPTN, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of miRNA processing activity versus STAT3 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	STAT3 →	+1.257	+0.141	<.001	<.001	3	12
KIDNEY	IL6 →	+4.287	+0.363	<.001	<.001	3	10
BLOOD_Lymphoma	OPTN →	+2.752	+0.125	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	EBI3 →	+1.456	+0.191	.004	.003	3	8
BREAST	OSMR →	+1.923	+0.119	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	SAA1 →	+3.094	+0.145	.002	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903799 vs STAT3 — BREAST

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