Negative regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSDHL, KDM1A, and GTF3C4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSDHL grouped by Negative regulation of miRNA processing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NSDHL →	-0.230	-1.909	.003	.002	3	2
BREAST	KDM1A →	-0.572	-1.640	.009	<.001	3	2
LUNG_SCLC	GTF3C4 →	-0.185	-1.885	.009	.006	2	2
LUNG_SCLC	SLITRK5 →	-0.425	-2.081	.005	.005	2	2
LUNG_SCLC	TBC1D10B →	-0.345	-1.885	.007	.006	2	2
LUNG_SCLC	BNC1 →	+0.200	+1.747	.009	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSDHL by Negative regulation of miRNA processing activity — BREAST

Explore this box plot interactively →