Negative regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Negative regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX3, LYL1, and CDHR3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of miRNA processing activity versus PRDX3 in LUNG_NSCLC_LUAD (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRDX3 →	+1.121	+1.853	.001	<.001	3	3
LUNG_SCLC	LYL1 →	-0.740	-1.609	.003	.005	3	2
LUNG_SCLC	CDHR3 →	+2.113	+1.598	<.001	<.001	3	2
LUNG_SCLC	LY6E →	+1.645	+1.598	.002	<.001	3	2
LUNG_SCLC	MTLN →	+0.876	+2.005	.001	<.001	3	2
LUNG_SCLC	HAUS7 →	-0.923	-2.005	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903799 vs PRDX3 — LUNG_NSCLC_LUAD

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