Negative regulation of monoatomic anion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of monoatomic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF1P5, RASGRF2, and ALPK2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic anion transport activity versus EIF1P5 in LUAD (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EIF1P5 →	+0.328	+0.163	<.001	.001	3	3
BRCA	RASGRF2 →	+0.555	+0.278	.001	.007	3	3
GBM	ALPK2 →	+0.853	+0.626	.008	<.001	3	3
HNSC	TUFT1 →	+0.999	+0.990	.003	.002	3	3
UCEC	MIR5093 →	-1.023	-0.637	.002	.002	3	3
LUAD	FCRL1 →	+0.693	+0.139	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903792 vs EIF1P5 — LUAD

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