Negative regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT6A, COL17A1, and PKP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of p38MAPK cascade activity versus KRT6A in OESOPHAGUS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KRT6A →	+5.978	+0.318	.005	<.001	3	3
OESOPHAGUS	COL17A1 →	+3.641	+0.282	.003	.002	3	3
OESOPHAGUS	PKP1 →	+4.788	+0.367	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ERI1 →	-1.076	-0.355	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	MCM7 →	-1.432	-0.308	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HSPA4 →	-1.289	-0.347	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903753 vs KRT6A — OESOPHAGUS

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