Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPE1P5, TRAP1, and NPW, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide activity versus HSPE1P5 in GBM (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSPE1P5 →	-0.316	-0.093	<.001	<.001	3	4
HNSC	TRAP1 →	+0.419	+0.065	<.001	<.001	3	4
HNSC	NPW →	+0.714	+0.089	.002	<.001	3	4
BRCA	ZNF133 →	-0.326	-0.097	.004	.001	3	4
UCEC	RAB32 →	-0.831	-0.074	.005	.007	3	4
OV	CPNE8-AS1 →	-0.963	-0.105	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903750 vs HSPE1P5 — GBM

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