Positive regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Positive regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIT2, MAGOH, and SRSF9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to mitochondrion activity versus GIT2 in BONE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GIT2 →	+0.815	+0.452	<.001	.008	3	6
LARGE_INTESTINE	MAGOH →	+0.667	+0.305	.007	.003	3	6
PANCREAS	SRSF9 →	+0.577	+0.319	.002	.005	3	6
SOFT_TISSUE	UBE2O →	+0.658	+0.399	.002	<.001	3	5
OVARY	MT-ND3 →	-0.749	-0.332	.008	.003	3	5
OVARY	SOAT1 →	+1.333	+0.489	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903749 vs GIT2 — BONE

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