Regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDB2, ETS1, and ORAI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDB2 grouped by Regulation of establishment of protein localization to mitochondrion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PHLDB2 →	-3.273	-0.145	.006	.004	3	5
SOFT_TISSUE	ETS1 →	-2.919	-0.146	.001	.003	3	4
LARGE_INTESTINE	ORAI2 →	-1.347	-0.174	.007	.002	3	4
OVARY	BDNF →	-1.743	-0.276	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	DNAJB12 →	-0.759	-0.244	.008	.008	3	4
SOFT_TISSUE	SFXN3 →	-2.680	-0.138	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDB2 by Regulation of establishment of protein localization to mitochondrion activity — SOFT_TISSUE

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