Regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, TRIO, and COX4I1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Regulation of establishment of protein localization to mitochondrion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAX →	-0.329	-0.101	.001	.006	3	6
SOFT_TISSUE	TRIO →	+0.248	+0.153	<.001	<.001	3	6
BREAST	COX4I1 →	-0.267	-0.092	<.001	<.001	3	6
BREAST	RAG2 →	+0.144	+0.092	.006	<.001	3	6
LUNG_NSCLC_LUAD	PPP1R12A →	+0.198	+0.055	.004	.004	3	5
STOMACH	UROD →	-0.452	-0.136	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Regulation of establishment of protein localization to mitochondrion activity — PANCREAS

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