Regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf216, CNOT9, and HMG20A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of protein localization to mitochondrion activity versus C1orf216 in LARGE_INTESTINE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf216 →	+0.871	+0.241	.003	<.001	3	7
PANCREAS	CNOT9 →	+0.590	+0.408	<.001	<.001	3	7
LIVER	HMG20A →	+0.685	+0.485	.007	.001	3	7
STOMACH	PSMC3IP →	+1.246	+0.353	<.001	.006	3	6
LUNG_SCLC	KPNA6 →	+0.673	+0.181	<.001	.005	3	6
PANCREAS	MRPL3 →	+0.669	+0.353	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903747 vs C1orf216 — LARGE_INTESTINE

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