Regulation of plasma membrane organization

Across TCGA patient cohorts, RNA activity of the Regulation of plasma membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR-AS1, CASP7, and AHNAK, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane organization activity versus CFLAR-AS1 in KIRC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	CFLAR-AS1 →	+0.532	+0.040	<.001	<.001	3	30
CHOL	CASP7 →	+1.360	+0.118	<.001	<.001	3	30
THYM	AHNAK →	+1.955	+0.083	<.001	<.001	3	29
UVM	MAP3K2 →	+1.107	+0.034	<.001	<.001	3	29
ESCA	RN7SKP16 →	+0.862	+0.058	<.001	<.001	3	29
UVM	ROCK1 →	+1.015	+0.036	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903729 vs CFLAR-AS1 — KIRC

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