Positive regulation of centriole elongation

Across TCGA patient cohorts, RNA activity of the Positive regulation of centriole elongation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES2, SIN3A_T435, and BRPF1_S860, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of centriole elongation activity versus CES2 in CCRCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CES2 →	-0.833	-0.040	<.001	<.001	3	4
HNSC	SIN3A_T435 →	+0.321	+0.050	.007	.002	3	4
HNSC	BRPF1_S860 →	+0.333	+0.057	.001	<.001	3	4
HNSC	BUD31 →	+0.340	+0.076	<.001	<.001	3	4
UCEC	SDC4 →	-0.652	-0.056	.001	.003	2	5
GBM	FANCD2_S1435 →	+0.805	+0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903724 vs CES2 — CCRCC

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