Regulation of aerobic respiration

Across TCGA patient cohorts, RNA activity of the Regulation of aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC102B, NDEL1, and FYN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of aerobic respiration activity versus CCDC102B in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC102B →	-0.634	-0.141	<.001	<.001	3	5
LUAD	NDEL1 →	-0.292	-0.175	.001	<.001	3	5
LSCC	FYN →	-0.513	-0.118	.001	.002	3	4
PDAC	TRBV5-7 →	-0.757	-0.106	<.001	<.001	3	4
COAD	TRBV13 →	-0.735	-0.145	.001	<.001	3	4
LSCC	FOLR1 →	-1.106	-0.089	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903715 vs CCDC102B — LSCC

Explore this scatter interactively →