"Positive regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, FERMT2, and INPPL1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTOR grouped by "Positive regulation of wound healing, spreading of epidermal cells"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MTOR →	-0.449	-0.353	<.001	<.001	3	12
CNS	FERMT2 →	-0.626	-0.430	<.001	.001	3	6
LUNG_NSCLC_LUAD	INPPL1 →	+0.183	+0.502	.001	.007	3	5
SKIN	FAM104A →	+0.107	+0.181	.002	.002	3	5
LIVER	TTC21A →	+0.274	+0.332	<.001	<.001	3	4
LARGE_INTESTINE	SAMD4B →	-0.253	-0.247	.007	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTOR by "Positive regulation of wound healing, spreading of epidermal cells" activity — SOFT_TISSUE

Explore this box plot interactively →