"Positive regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB42, REEP3, and RASA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB42 grouped by "Positive regulation of wound healing, spreading of epidermal cells"-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB42 →	-0.933	-0.151	.002	.002	3	4
SKIN	REEP3 →	+0.757	+0.234	.001	<.001	3	4
BREAST	RASA4 →	-1.207	-0.163	.006	.007	3	3
OESOPHAGUS	SHFL →	-1.352	-0.239	<.001	.003	3	3
BREAST	MORC4 →	+1.053	+0.229	.007	.006	3	3
BREAST	EFCAB13 →	-0.675	-0.157	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB42 by "Positive regulation of wound healing, spreading of epidermal cells" activity — BREAST

Explore this box plot interactively →