"Positive regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RREB1, HECTD1, and PPP4R3A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of wound healing, spreading of epidermal cells" activity versus RREB1 in STOMACH (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RREB1 →	+0.990	+0.167	<.001	<.001	3	11
STOMACH	HECTD1 →	+0.911	+0.165	<.001	.003	3	7
LUNG_NSCLC_LUAD	PPP4R3A →	+0.748	+0.094	<.001	<.001	3	7
SOFT_TISSUE	BEND3 →	+0.829	+0.110	<.001	<.001	3	7
LARGE_INTESTINE	ANKS1A →	+0.678	+0.082	<.001	<.001	3	7
STOMACH	L2HGDH →	+0.822	+0.154	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903691 vs RREB1 — STOMACH

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