"Positive regulation of wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLC3, TIMM9, and PGM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of wound healing, spreading of epidermal cells" activity versus KLC3 in OVARY (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KLC3 →	-1.850	-1.042	.009	.009	3	5
OESOPHAGUS	TIMM9 →	+0.769	+0.422	.003	.001	3	4
LIVER	PGM3 →	+1.417	+1.390	.009	.005	3	4
BLOOD_Leukemia	SLC22A23 →	+1.270	+0.790	.002	.001	3	4
OESOPHAGUS	RPL36AL →	+0.945	+0.500	<.001	<.001	3	4
BREAST	MR1 →	-1.056	-0.934	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903691 vs KLC3 — OVARY

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