Positive regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of sprouting angiogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKM, S100A1, and PDPK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKM grouped by Positive regulation of sprouting angiogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PKM →	-0.381	-0.347	<.001	<.001	2	9
SOFT_TISSUE	S100A1 →	-0.398	-1.202	.001	<.001	3	8
SKIN	PDPK1 →	-0.240	-1.093	<.001	.002	3	6
LUNG_NSCLC_LUAD	PLK1 →	-0.427	-0.636	.001	.005	2	6
OESOPHAGUS	SERPINB8 →	-0.215	-1.017	.005	.007	3	4
OESOPHAGUS	ADIPOQ →	+0.132	+1.067	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKM by Positive regulation of sprouting angiogenesis activity — PANCREAS

Explore this box plot interactively →