Positive regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PORCN, FAH, and H1-4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PORCN grouped by Positive regulation of sprouting angiogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PORCN →	-0.714	-0.379	.003	.004	3	4
BLOOD_Leukemia	FAH →	-1.956	-0.505	<.001	<.001	3	4
BLOOD_Myeloma	H1-4 →	+1.108	+0.504	.006	.009	3	4
OVARY	PRKCQ →	+1.309	+0.906	.009	.006	3	4
LIVER	IPO13 →	-0.785	-1.745	.003	.008	3	4
LUNG_NSCLC_LUAD	KYNU →	-2.824	-0.675	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PORCN by Positive regulation of sprouting angiogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →