Positive regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of sprouting angiogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H2, WFDC10B, and TNFRSF18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2H2 grouped by Positive regulation of sprouting angiogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GTF2H2 →	+0.314	+0.247	.005	.006	3	4
LUNG_SCLC	WFDC10B →	-0.208	-0.221	.004	.009	3	4
LUNG_SCLC	TNFRSF18 →	-0.178	-0.278	.009	.002	3	4
LUNG_NSCLC_LUSC	IL18BP →	+0.364	+0.367	.003	.006	3	4
BLOOD_Lymphoma	PCBP1 →	-0.706	-0.199	.009	.005	3	4
LUNG_SCLC	UBB →	+0.370	+0.210	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2H2 by Positive regulation of sprouting angiogenesis activity — URINARY_TRACT

Explore this box plot interactively →