Positive regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAGP, ESYT2, and MDFI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sprouting angiogenesis activity versus SMAGP in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMAGP →	+0.870	+0.230	<.001	.004	2	6
BONE	ESYT2 →	+1.166	+0.274	.003	.003	3	5
LIVER	MDFI →	+2.385	+0.326	<.001	<.001	3	4
BLOOD_Leukemia	ASPRV1 →	-0.587	-0.123	.002	.003	3	4
BLOOD_Myeloma	EPHB4 →	+1.742	+0.182	<.001	.002	3	4
BLOOD_Myeloma	RASSF8 →	-1.541	-0.194	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903672 vs SMAGP — UPPER_AERODIGESTIVE_TRACT

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