Negative regulation of sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND2, TNFRSF11B, and C20orf203, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sprouting angiogenesis activity versus CCND2 in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCND2 →	+0.500	+0.610	<.001	.006	3	4
LUAD	TNFRSF11B →	+0.606	+0.222	.002	.008	3	3
BRCA	C20orf203 →	+0.067	+0.622	.002	.003	3	3
PDAC	MMP16 →	+0.312	+0.434	.007	.008	2	4
PDAC	RNF150 →	+0.292	+0.554	.001	<.001	3	3
OV	RFX5 →	-0.393	-0.138	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903671 vs CCND2 — PDAC

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