Negative regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF562, TMEM220, and LBH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF562 grouped by Negative regulation of sprouting angiogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF562 →	+0.554	+0.962	.006	.003	3	5
CNS	TMEM220 →	+1.035	+0.803	.001	.003	3	5
BREAST	LBH →	+1.910	+0.958	.006	<.001	3	5
SOFT_TISSUE	ADGRL2 →	+3.541	+1.279	<.001	<.001	3	4
OVARY	FABP3 →	+2.557	+0.839	<.001	.003	3	4
BONE	YBX1 →	+1.269	+1.557	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF562 by Negative regulation of sprouting angiogenesis activity — PANCREAS

Explore this box plot interactively →