Negative regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of sprouting angiogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX6, GABRP, and PRKAG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBX6 grouped by Negative regulation of sprouting angiogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CBX6 →	+0.200	+1.411	.008	<.001	3	5
SKIN	GABRP →	-0.168	-0.318	.003	.002	3	4
CNS	PRKAG3 →	-0.200	-0.244	<.001	.001	3	3
CNS	SNRPB2 →	+0.503	+0.277	<.001	<.001	3	3
CNS	RBPMS2 →	-0.143	-0.234	.004	.008	2	4
SOFT_TISSUE	DHX38 →	-0.635	-1.471	.008	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBX6 by Negative regulation of sprouting angiogenesis activity — SOFT_TISSUE

Explore this box plot interactively →