Regulation of sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF114, SBNO2, and HMOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF114 grouped by Regulation of sprouting angiogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNF114 →	-0.537	-0.484	.006	<.001	3	4
LIVER	SBNO2 →	-0.954	-1.153	.001	.002	3	3
OVARY	HMOX1 →	-3.333	-0.828	<.001	.004	3	3
CNS	CAMKMT →	+0.560	+0.977	.006	.004	2	4
BLOOD_Leukemia	HOMER2 →	-2.328	-0.639	.003	.005	3	3
BLOOD_Leukemia	SCAMP2 →	-0.664	-0.342	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF114 by Regulation of sprouting angiogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →