Regulation of complement-dependent cytotoxicity

Across TCGA patient cohorts, RNA activity of the Regulation of complement-dependent cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1, MLPH, and SPARCL1_S198, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of complement-dependent cytotoxicity activity versus TNKS1BP1 in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TNKS1BP1 →	+0.241	+0.070	<.001	.001	3	6
LUAD	MLPH →	+0.570	+0.055	<.001	.001	3	6
BRCA	SPARCL1_S198 →	+0.875	+0.063	.004	.006	3	6
UCEC	HAUS1 →	-0.247	-0.150	.001	.001	3	6
LUAD	UBE2S →	-0.476	-0.078	<.001	<.001	3	6
UCEC	C1orf116 →	+0.852	+0.126	.001	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903659 vs TNKS1BP1 — LUAD

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