Regulation of complement-dependent cytotoxicity

Across TCGA cell cohorts, RNA activity of the Regulation of complement-dependent cytotoxicity pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STKLD1, SIRPB2, and KIR3DL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STKLD1 grouped by Regulation of complement-dependent cytotoxicity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STKLD1 →	-0.296	-1.414	.001	<.001	3	3
CNS	SIRPB2 →	+0.356	+1.414	.008	<.001	3	2
LUNG_NSCLC_LUAD	KIR3DL2 →	-0.258	-1.254	.003	.005	2	3
LARGE_INTESTINE	HMX3 →	+0.168	+1.529	.005	.001	3	2
URINARY_TRACT	CA10 →	-0.315	-1.928	.001	<.001	3	2
CNS	SULT1E1 →	+0.453	+1.414	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STKLD1 by Regulation of complement-dependent cytotoxicity activity — CNS

Explore this box plot interactively →