Positive regulation of DNA catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV4-1, BNIP3, and RNU6-881P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA catabolic process activity versus IGKV4-1 in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGKV4-1 →	+2.214	+0.117	.001	.001	3	3
UCEC	BNIP3 →	-0.956	-0.399	<.001	.001	3	3
HNSC	RNU6-881P →	+0.564	+0.223	<.001	<.001	3	3
LUAD	SLC2A6 →	+0.510	+0.145	<.001	.005	3	3
LSCC	NUGGC →	+0.771	+0.171	.003	.009	2	4
CCRCC	RPS15AP11 →	+0.316	+0.549	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903626 vs IGKV4-1 — BRCA

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