Regulation of DNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH7, PIFO, and RAD17P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA catabolic process activity versus DNAH7 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNAH7 →	+0.577	+0.151	<.001	.002	3	5
LUAD	PIFO →	+0.948	+0.193	.001	<.001	3	4
LUAD	RAD17P1 →	+0.809	+0.149	.007	<.001	3	4
BRCA	ASPA →	+0.531	+0.152	.004	.003	3	4
LSCC	KNSTRN →	-0.542	-0.234	<.001	<.001	3	4
BRCA	C2orf73 →	+0.433	+0.174	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903624 vs DNAH7 — BRCA

Explore this scatter interactively →