Positive regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC46A1, CIAO3, and GBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC46A1 grouped by Positive regulation of autophagy of mitochondrion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC46A1 →	+0.758	+0.211	.003	.001	3	4
BREAST	CIAO3 →	+0.683	+0.294	<.001	<.001	3	4
LIVER	GBP1 →	-1.986	-0.251	.001	.001	3	4
LIVER	GLIPR1 →	-3.241	-0.292	.004	.002	3	4
BREAST	MSI2 →	+1.558	+0.260	.001	.002	3	4
BREAST	TMEM186 →	+0.454	+0.279	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC46A1 by Positive regulation of autophagy of mitochondrion activity — BREAST

Explore this box plot interactively →