Positive regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagy of mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BOLA2B, BOLA2, and HUWE1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagy of mitochondrion activity versus BOLA2B in BREAST (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BOLA2B →	+2.620	+0.344	<.001	<.001	3	17
BREAST	BOLA2 →	+2.620	+0.344	<.001	<.001	3	17
URINARY_TRACT	HUWE1 →	+1.535	+0.274	.002	.002	3	16
LARGE_INTESTINE	STUB1 →	+0.952	+0.264	<.001	<.001	3	15
OESOPHAGUS	PFDN1 →	+1.557	+0.310	<.001	<.001	3	15
LUNG_NSCLC_LUSC	PARK7 →	+2.635	+0.584	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903599 vs BOLA2B — BREAST

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