Positive regulation of gap junction assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of gap junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SMCHD1, and CSRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gap junction assembly activity versus RSU1 in COAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RSU1 →	+0.409	+0.063	<.001	<.001	3	6
LUAD	SMCHD1 →	-0.227	-0.102	.004	.001	3	6
COAD	CSRP1 →	+0.645	+0.055	.003	.003	3	6
COAD	FERMT2 →	+0.487	+0.092	.002	<.001	3	6
COAD	LPP →	+0.417	+0.060	.004	<.001	3	6
COAD	LRP1 →	+0.249	+0.066	.008	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903598 vs RSU1 — COAD

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