Regulation of histamine secretion by mast cell

Across TCGA cell cohorts, RNA activity of the Regulation of histamine secretion by mast cell pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPUL2, TPST1, and FBXO3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HNRNPUL2 grouped by Regulation of histamine secretion by mast cell-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HNRNPUL2 →	-0.870	-2.359	.002	<.001	3	4
PANCREAS	TPST1 →	+0.817	+1.604	.007	<.001	3	4
LUNG_NSCLC_LUAD	FBXO3 →	-0.336	-0.879	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	THAP1 →	-0.944	-1.483	<.001	.004	2	4
LIVER	BCL11A →	-2.410	-2.418	.008	.007	3	3
BREAST	NFATC4 →	+2.049	+0.853	.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HNRNPUL2 by Regulation of histamine secretion by mast cell activity — LIVER

Explore this box plot interactively →