Regulation of histamine secretion by mast cell

Across TCGA cell cohorts, RNA activity of the Regulation of histamine secretion by mast cell pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP8, ALDH3B1, and DIMT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of histamine secretion by mast cell activity versus VAMP8 in BLOOD_Leukemia (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VAMP8 →	+3.028	+1.081	.001	<.001	3	7
LUNG_NSCLC_LUSC	ALDH3B1 →	+4.483	+1.645	.007	<.001	3	4
BLOOD_Leukemia	DIMT1 →	-0.727	-0.862	<.001	.006	3	4
BLOOD_Leukemia	BIRC5 →	-0.940	-1.094	<.001	.001	3	4
BLOOD_Leukemia	PLB1 →	+2.456	+0.735	<.001	.002	3	4
BLOOD_Leukemia	PLCXD2 →	-0.557	-0.671	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903593 vs VAMP8 — BLOOD_Leukemia

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