Negative regulation of response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL32, SHPRH, and SUPT16H, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to endoplasmic reticulum stress activity versus MRPL32 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRPL32 →	-0.281	-0.141	.002	.002	3	6
LSCC	SHPRH →	-0.372	-0.193	.004	<.001	3	6
LSCC	SUPT16H →	-0.427	-0.136	<.001	<.001	3	6
LSCC	SMC3 →	-0.414	-0.135	<.001	<.001	3	5
LSCC	CBX1 →	-0.549	-0.123	<.001	<.001	3	5
LSCC	NAA35 →	-0.408	-0.129	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903573 vs MRPL32 — LSCC

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