Positive regulation of protein localization to cilium

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00653, ARL6, and S100A16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cilium activity versus LINC00653 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC00653 →	+0.542	+0.579	<.001	.006	3	4
LSCC	ARL6 →	+0.344	+0.537	.006	.004	3	3
UCEC	S100A16 →	-1.019	-0.468	<.001	.007	3	3
BRCA	C17orf100 →	+0.452	+0.608	<.001	<.001	3	3
COAD	MATN1-AS1 →	+0.254	+0.809	.001	.002	3	3
BRCA	BOLA3-AS1 →	+0.724	+0.666	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903566 vs LINC00653 — BRCA

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