Negative regulation of tumor necrosis factor superfamily cytokine production

Across TCGA patient cohorts, RNA activity of the Negative regulation of tumor necrosis factor superfamily cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL15, NCR1, and SIGLEC14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tumor necrosis factor superfamily cytokine production activity versus IL15 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL15 →	+0.610	+0.569	<.001	.003	3	4
HNSC	NCR1 →	+0.418	+0.487	<.001	<.001	3	4
UCEC	SIGLEC14 →	+0.479	+0.532	.001	<.001	3	4
BRCA	EPB41L4A →	-0.722	-0.650	<.001	.001	3	4
LUAD	SOD2 →	+0.459	+0.606	<.001	<.001	3	4
LUAD	CTDSPL →	-0.551	-0.924	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903556 vs IL15 — GBM

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