Release of sequestered calcium ion into cytosol by endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Release of sequestered calcium ion into cytosol by endoplasmic reticulum pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTN5, ANKRD34B, and NECAB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NTN5 grouped by Release of sequestered calcium ion into cytosol by endoplasmic reticulum-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NTN5 →	+0.215	+1.234	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ANKRD34B →	+0.243	+1.120	<.001	<.001	3	4
PANCREAS	NECAB1 →	+0.145	+1.285	.002	<.001	3	3
OVARY	PYGO2 →	-0.224	-0.951	.003	.004	3	3
LIVER	ATP1A2 →	-0.239	-1.280	.002	.003	3	3
LARGE_INTESTINE	CLSTN3 →	-0.337	-1.228	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NTN5 by Release of sequestered calcium ion into cytosol by endoplasmic reticulum activity — SKIN

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