Release of sequestered calcium ion into cytosol by endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Release of sequestered calcium ion into cytosol by endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAXD, MMP7, and ASNSD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Release of sequestered calcium ion into cytosol by endoplasmic reticulum activity versus NAXD in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAXD →	+1.308	+1.103	.002	.003	3	4
BREAST	MMP7 →	-5.620	-1.413	.002	.001	3	2
BREAST	ASNSD1 →	-0.589	-1.463	.004	.008	2	3
BREAST	WNK2 →	-2.317	-1.007	.001	.008	3	2
BREAST	DAND5 →	-0.536	-1.195	.008	.007	3	2
BREAST	NANOS3 →	-0.507	-1.024	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903514 vs NAXD — BREAST

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