Endoplasmic reticulum to cytosol transport

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum to cytosol transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDKL5_S407, ADD3_S42, and NPY1R_S368, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to cytosol transport activity versus CDKL5_S407 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDKL5_S407 →	+0.816	+0.057	<.001	<.001	3	5
LUAD	ADD3_S42 →	+0.344	+0.037	<.001	<.001	3	5
CCRCC	NPY1R_S368 →	+0.754	+0.025	.001	.004	3	5
COAD	PPP1R3D_S78 →	-0.446	-0.034	.004	<.001	3	5
LUAD	KMT2C_S4300 →	-0.655	-0.046	<.001	.001	3	5
OV	SCYL1_S754 →	+0.579	+0.033	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903513 vs CDKL5_S407 — OV

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