Positive regulation of mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBIP, IMPA2, and PRR15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IKBIP grouped by Positive regulation of mitotic cytokinesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IKBIP →	-1.051	-0.182	<.001	<.001	3	6
SOFT_TISSUE	IMPA2 →	+2.041	+0.438	.007	.005	3	6
URINARY_TRACT	PRR15 →	+4.572	+0.340	<.001	.002	3	6
BONE	GOLGA8K →	-0.877	-0.324	.009	.005	3	5
SOFT_TISSUE	LRRC8C →	-1.752	-0.371	.001	.004	3	5
URINARY_TRACT	TPM2 →	-5.104	-0.380	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IKBIP by Positive regulation of mitotic cytokinesis activity — LARGE_INTESTINE

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