Positive regulation of mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDHD, KRT18, and CDCA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cytokinesis activity versus SDHD in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SDHD →	-0.717	-1.057	.008	.006	3	4
OESOPHAGUS	KRT18 →	-2.147	-0.232	<.001	.001	3	4
BLOOD_Lymphoma	CDCA3 →	+0.893	+0.176	<.001	.009	3	4
BLOOD_Leukemia	SNTA1 →	+1.112	+0.242	.001	.004	3	4
BLOOD_Leukemia	CD300C →	-1.347	-0.157	.001	.001	3	4
LUNG_NSCLC_LUSC	USF1 →	-0.708	-0.244	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903490 vs SDHD — STOMACH

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