Positive regulation of cell maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1, SLC9A3R1, and ACAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell maturation activity versus LSP1 in PDAC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LSP1 →	+0.254	+0.051	.003	.002	3	6
LSCC	SLC9A3R1 →	+0.499	+0.109	.004	<.001	3	5
HNSC	ACAP2 →	+0.318	+0.097	.005	<.001	3	5
CCRCC	PIK3R1 →	+0.239	+0.091	<.001	<.001	3	5
HNSC	MYO1B →	-0.502	-0.084	<.001	<.001	3	5
UCEC	SASH3 →	+0.426	+0.085	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903431 vs LSP1 — PDAC

Explore this scatter interactively →