Positive regulation of reactive oxygen species biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR4, LILRB2, and ITGAX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of reactive oxygen species biosynthetic process activity versus S1PR4 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S1PR4 →	+0.624	+0.248	.008	.001	3	5
UCEC	LILRB2 →	+0.507	+0.447	.001	.004	3	5
PDAC	ITGAX →	+0.449	+0.195	.003	.003	3	5
BRCA	SH2D1A →	+0.811	+0.200	<.001	<.001	3	5
CCRCC	RIPOR2 →	+0.762	+0.194	<.001	<.001	3	5
BRCA	LCP2 →	+0.704	+0.279	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903428 vs S1PR4 — BRCA

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