Positive regulation of reactive oxygen species biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3, NABP1, and RAB27A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of reactive oxygen species biosynthetic process activity versus C3 in LUNG_NSCLC_LUSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C3 →	+5.876	+0.491	.006	.008	3	7
SOFT_TISSUE	NABP1 →	+5.000	+1.674	<.001	<.001	3	5
BLOOD_Leukemia	RAB27A →	+1.593	+0.542	<.001	.001	3	5
BLOOD_Leukemia	ODF3B →	+1.524	+0.512	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	TMEM97 →	-2.132	-0.435	<.001	.009	3	4
UPPER_AERODIGESTIVE_TRACT	KLHL23 →	-1.676	-0.537	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903428 vs C3 — LUNG_NSCLC_LUSC

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