Regulation of synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle recycling pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, RPL4, and RPL6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle recycling activity versus HIP1 in CCRCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HIP1 →	+0.191	+0.040	.002	<.001	3	6
CCRCC	RPL4 →	-0.314	-0.043	.002	<.001	3	5
GBM	RPL6 →	-0.669	-0.094	<.001	<.001	3	5
HNSC	EEF1D →	-0.217	-0.037	<.001	.007	3	5
CCRCC	EIF3E →	-0.137	-0.048	.007	.002	3	5
GBM	IRAG1 →	+0.526	+0.076	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903421 vs HIP1 — CCRCC

Explore this scatter interactively →